The buzz of nursing facilities is declining as increasingly more elderly folks are relinquishing their drive to live in these establishments in their last days and nights. But this is not just the issue of the elderly people as it is also an issue for families as well as relatives who are responsible for their healthiness. There?s normally a challenge with regard to giving their elderly fathers and mothers to assisted living facilities which they often don?t favor. Therefore, they?re opting for home care facilities to ensure that their aging seniors may appreciate freedom. Luckily, you can find firms which may enable you to decide what exactly is best for your elderly loved ones.
In case your older fathers and mothers choose to live in the comfort and ease of their own houses, then it will be much better if you employ the assistance of Home health companies Naples. Home care companies are ready to be of use to your family members, twenty-four hours a day, seven days a week. They may also be flexible on time dependant upon the needs of the senior citizen. Their major duty would be to assist senior individuals during the days where they should recognize the circumstances of the retirement years and live a life filled with fulfillment as well as joy.
Utilizing proficient Homecare agency Miami implies working together with competent professionals in the area of caregiving. They?re well prepared to take care of your elderly family members and you may start your own lives because you realize they?re in fantastic hands. Home care firms also offer you a better service for your cash in comparison to nursing facilities. In fact, home based care firms benefit your elderly fathers and mothers as well as your family members on the whole.
Alzheimers illness is one of the common conditions encountered by most elderly folks. A person with this particular illness suffers from slow loss of memory till they fully forget about who they may be and precisely how to function appropriately. The home based care service employees are prepared with expertise that can help combat this particular disease. The home based care specialists will remind seniors of the things they preferred to carry out, who they were and what was their personality. These activities effectively enhance the character of the elderly despite the circumstances.
Aged folks have one reason why they choose Ft. Myers home care companies over nursing facilities and that is because they really want much more attention as well as comfort. Most sufferers within nursing facilities are suffering from dullness as well as unhappiness which you wouldn?t wish to affect your elderly loved ones. Senior citizen home based care solutions are much more better given that they may live in a place they?re pretty familiar with. Retirement communities also offer services at higher costs senior citizen home based care which is a clear benefit for people.
If you never have enough money but still wants the ideal for your own elderly loved ones then you should research senior citizen home based care companies. They?re the better option to nursing facilities.
01. March 2012 by admin
Categories: genral |
Tags: Ft. Myers home care companies, Home care agency Miami, Home care companies Ft. Myers, Home health companies Naples, Homecare agency Miami, Homecare companies Ft. Myers, Miami home care agency, Naples home health companies |
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SAN DIEGO, Feb. 29, 2012 /PRNewswire/ ??Polaris Group (Polaris) today announced that it has dosed the first patient in a Phase 1 clinical trial evaluating its lead cancer therapeutic, pegylated arginine deiminase (ADI-PEG 20), in pediatric patients with emphasis on leukemia, lymphoma and sarcoma cancers. These three cancers represent approximately 50% of all cancers that occur in the pediatric population.
Patients with advanced cancers who have failed current therapy will be eligible to be treated with ADI-PEG 20. In addition, a tumor specimen from these potentially eligible patients must be deficient in expression of the enzyme argininosuccinate synthetase, the rate limiting step in formation of arginine. Patients will be enrolled into cohorts of increased doses of ADI-PEG 20, and will receive weekly intramuscular injections of ADI-PEG 20 until disease progression.? The primary endpoints of the study are safety and efficacy, and secondary endpoints will include finding the maximum tolerated dose of ADI-PEG 20 in a pediatric tumor population.
The rationale for the use of ADI-PEG 20 in these cancers was previously reported by Polaris collaborators, using both cell based assays and xenograft mouse models. In addition, they found a high percentage of these cancer tissue specimens require arginine. This Phase 1 clinical study is being conducted at MD Anderson Cancer Center, Houston, Texas.
?We are delighted to begin this first study of ADI-PEG 20 in pediatric patients,? said John Bomalaski, M.D., Executive Vice President, Medical Affairs, of Polaris. ?We believe ADI-PEG 20 is a promising cancer therapeutic for these cancers, and we plan to initiate Phase 2 studies in adults with these cancers. ADI-PEG 20 as monotherapy is already in a Phase 3 global trial for patients with hepatocellular carcinoma, and in Phase 2 trials for patients with small cell lung carcinoma and mesothelioma. In addition, a Phase 1 trial in prostate cancer in combination with docetaxel is ongoing. Thus ADI-PEG 20 has potential for therapeutic benefit in a number of cancers, and we look forward to continuing clinical development.?
Additional information about the trial can be found online at http://clinicaltrials.gov/ct2/show/NCT01528384?term=arginine+deiminaserank=4.
About Pediatric Leukemia, Lymphoma and Sarcoma
Leukemia, lymphoma and sarcoma account for approximately 50% of childhood cancers. Leukemias are cancers of the blood, and account for approximately one-third of all cancers in the pediatric population. The major types are acute lymphocytic leukemia and acute myeloid leukemia. Lymphomas are cancers of the lymph nodes and related tissues. They account for approximately 10% of pediatric cancers. The major types are Hodgkin and non-Hodgkin lymphoma. Sarcomas and bone cancers attack either the soft tissues around the bone or the bone itself. They account for approximately 8 % of childhood cancers. The most common are rhabdomyosarcoma, osteosarcoma and Ewing sarcoma.
About ADI-PEG 20
ADI-PEG 20 is a biologic being developed by Polaris to treat cancers carrying a major metabolic defect that renders them, unlike normal cells, unable to make arginine internally. Because arginine is one of the 20 amino acids that are essential for protein synthesis and survival of cells, these cancer cells become dependent upon the external supply of arginine to survive and grow. ADI-PEG 20 works by systemically depleting the external supply of arginine, which causes these arginine-dependent cancer cells to die while leaving the normal cells unharmed.
Multiple cancers have been reported to have a high degree of arginine-dependency.
About Polaris Group
Polaris Group is a privately held multinational biopharmaceutical company that specializes in the research and development of protein drugs to treat cancer and other debilitating diseases. The company?s lead therapeutic, ADI-PEG 20, is currently being evaluated in a pivotal Phase 3 trial for hepatocellular carcinoma. Polaris is also investigating ADI-PEG 20 as a treatment for other arginine-dependent cancers, such as melanoma, leukemia, lymphoma, sarcoma and pancreatic cancer. In addition to the ADI-PEG 20 project, Polaris is researching and developing other biotherapeutic agents and has a small molecule drug program that utilizes a rational structure-based approach to design novel compounds that inhibit the biological function of cancer-related protein targets.
For additional information please visit www.polarispharma.com.
UF scientists name new ancient camels from Panama Canal excavationPublic release date: 29-Feb-2012 [ | E-mail | Share ]
Contact: Paul Ramey pramey@flmnh.ufl.edu 352-273-2054 University of Florida
GAINESVILLE, Fla. --- The discovery of two new extinct camel species by University of Florida scientists sheds new light on the history of the tropics, a region containing more than half the world's biodiversity and some of its most important ecosystems.
Appearing online this week in the Journal of Vertebrate Paleontology, the study is the first published description of a fossil mammal discovered as part of an international project in Panama. Funded with a grant from the National Science Foundation, UF paleontologists and geologists are working with the Panama Canal Authority and scientists at the Smithsonian Tropical Research Institute to make the most of a five-year window of excavations during Panama Canal expansions that began in 2009.
The discovery by Florida Museum of Natural History researchers extends the distribution of mammals to their southernmost point in the ancient tropics of Central America. The tropics contain some of the world's most important ecosystems, including rain forests that regulate climate systems and serve as a vital source of food and medicine, yet little is known of their history because lush vegetation prevents paleontological excavations.
"We're discovering this fabulous new diversity of animals that lived in Central America that we didn't even know about before," said co-author Bruce MacFadden, vertebrate paleontology curator at the Florida Museum on the UF campus and co-principal investigator on the NSF grant funding the project. "The family originated about 30 million years ago and they're found widespread throughout North America, but prior to this discovery, they were unknown south of Mexico."
Researchers described two species of ancient camels that are also the oldest mammals found in Panama: Aguascalietia panamaensis and Aguascalientia minuta. Distinguished from each other mainly by their size, the camels belong to an evolutionary branch of the camel family separate from the one that gave rise to modern camels based on different proportions of teeth and elongated jaws.
"Some descriptions say these are 'crocodile-like' camels because they have more elongated snouts than you would expect," said lead author Aldo Rincon, a UF geology doctoral student. "They were probably browsers in the forests of the ancient tropics. We can say that because the crowns are really short."
Rincon discovered the fossils in the Las Cascadas formation, unearthing pieces of a jaw belonging to the same animal over a span of two years, he said.
"When I came back to the museum, I started putting everything together and realized, 'Oh wow, I have a nearly complete jaw,' " Rincon said.
The study shows that despite Central America's close proximity to South America, there was no connection between continents because mammals in the area 20 million years ago all had North American origins. The Isthmus of Panama formed about 15 million years later and the fauna crossed to South America 2.5 to 3 million years ago, MacFadden said.
Barry Albright, a professor of earth science at the University of North Florida who studied the early Miocene fauna of the Gulf Coast Plain, said he was surprised by the similarity of the Central American fauna.
"To me, it's slightly unexpected," Albright said. "That's a large latitudinal gradient between the Gulf Coastal Plain and Panama, yet we're seeing the same mammals, so perhaps that tells us something about climate over that interval of time and dispersal patterns of some mammals over that interval of time."
Camels belong to a group of even-toed ungulates that includes cattle, goats, sheep, deer, buffalo and pigs. Other fossil mammals discovered in Panama from the early Miocene have been restricted to those also found in North America at the time. While researchers are sure the ancient camels were herbivores that likely browsed in forests, they are still analyzing seeds and pollen to better understand the environment of the ancient tropics.
"People think of camels as being in the Old World, but their distribution in the past is different than what we know today," MacFadden said. "The ancestors of llamas originated in North America and then when the land bridge formed about 4 to 5 million years ago, they dispersed into South America and evolved into the llama, alpaca, guanaco and vicua."
Researchers will continue excavating deposits from the Panama Canal during construction to widen and straighten the channel and build new locks, expected to continue through 2014. The project is funded by a $3.8 million NSF grant to develop partnerships between the U.S. and Panama and engage the next generation of scientists in paleontological and geological discoveries along the canal. Study co-authors include Jonathan Bloch of UF, and Catalina Suarez and Carlos Jaramillo of the Smithsonian Tropical Research Institute.
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UF scientists name new ancient camels from Panama Canal excavationPublic release date: 29-Feb-2012 [ | E-mail | Share ]
Contact: Paul Ramey pramey@flmnh.ufl.edu 352-273-2054 University of Florida
GAINESVILLE, Fla. --- The discovery of two new extinct camel species by University of Florida scientists sheds new light on the history of the tropics, a region containing more than half the world's biodiversity and some of its most important ecosystems.
Appearing online this week in the Journal of Vertebrate Paleontology, the study is the first published description of a fossil mammal discovered as part of an international project in Panama. Funded with a grant from the National Science Foundation, UF paleontologists and geologists are working with the Panama Canal Authority and scientists at the Smithsonian Tropical Research Institute to make the most of a five-year window of excavations during Panama Canal expansions that began in 2009.
The discovery by Florida Museum of Natural History researchers extends the distribution of mammals to their southernmost point in the ancient tropics of Central America. The tropics contain some of the world's most important ecosystems, including rain forests that regulate climate systems and serve as a vital source of food and medicine, yet little is known of their history because lush vegetation prevents paleontological excavations.
"We're discovering this fabulous new diversity of animals that lived in Central America that we didn't even know about before," said co-author Bruce MacFadden, vertebrate paleontology curator at the Florida Museum on the UF campus and co-principal investigator on the NSF grant funding the project. "The family originated about 30 million years ago and they're found widespread throughout North America, but prior to this discovery, they were unknown south of Mexico."
Researchers described two species of ancient camels that are also the oldest mammals found in Panama: Aguascalietia panamaensis and Aguascalientia minuta. Distinguished from each other mainly by their size, the camels belong to an evolutionary branch of the camel family separate from the one that gave rise to modern camels based on different proportions of teeth and elongated jaws.
"Some descriptions say these are 'crocodile-like' camels because they have more elongated snouts than you would expect," said lead author Aldo Rincon, a UF geology doctoral student. "They were probably browsers in the forests of the ancient tropics. We can say that because the crowns are really short."
Rincon discovered the fossils in the Las Cascadas formation, unearthing pieces of a jaw belonging to the same animal over a span of two years, he said.
"When I came back to the museum, I started putting everything together and realized, 'Oh wow, I have a nearly complete jaw,' " Rincon said.
The study shows that despite Central America's close proximity to South America, there was no connection between continents because mammals in the area 20 million years ago all had North American origins. The Isthmus of Panama formed about 15 million years later and the fauna crossed to South America 2.5 to 3 million years ago, MacFadden said.
Barry Albright, a professor of earth science at the University of North Florida who studied the early Miocene fauna of the Gulf Coast Plain, said he was surprised by the similarity of the Central American fauna.
"To me, it's slightly unexpected," Albright said. "That's a large latitudinal gradient between the Gulf Coastal Plain and Panama, yet we're seeing the same mammals, so perhaps that tells us something about climate over that interval of time and dispersal patterns of some mammals over that interval of time."
Camels belong to a group of even-toed ungulates that includes cattle, goats, sheep, deer, buffalo and pigs. Other fossil mammals discovered in Panama from the early Miocene have been restricted to those also found in North America at the time. While researchers are sure the ancient camels were herbivores that likely browsed in forests, they are still analyzing seeds and pollen to better understand the environment of the ancient tropics.
"People think of camels as being in the Old World, but their distribution in the past is different than what we know today," MacFadden said. "The ancestors of llamas originated in North America and then when the land bridge formed about 4 to 5 million years ago, they dispersed into South America and evolved into the llama, alpaca, guanaco and vicua."
Researchers will continue excavating deposits from the Panama Canal during construction to widen and straighten the channel and build new locks, expected to continue through 2014. The project is funded by a $3.8 million NSF grant to develop partnerships between the U.S. and Panama and engage the next generation of scientists in paleontological and geological discoveries along the canal. Study co-authors include Jonathan Bloch of UF, and Catalina Suarez and Carlos Jaramillo of the Smithsonian Tropical Research Institute.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Public release date: 29-Feb-2012
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